Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis
نویسندگان
چکیده
منابع مشابه
Evaluation of ventilation maldistribution as an early indicator of lung disease in children with cystic fibrosis.
Many children with cystic fibrosis (CF), receiving modern, aggressive CF care, have normal spirometry results. This study aimed to see if homogeneity of ventilation distribution is impaired early in the course of CF lung disease, and if ventilation inhomogeneity is a more frequent finding than abnormal spirometry in children benefiting from modern CF care. The study compared spirometry findings...
متن کاملDetection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI.
Hyperpolarised 3He ventilation-MRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6-16 years) with clinically stable mild cystic fibrosis (CF) (FEV1>-1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ventilation-MRI was the most sensitive method of detecting abnormalities, present in 89% of patients with CF, com...
متن کاملDetection of early sub-clinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarized gas MRI
POLARIS, Academic Radiology, University of Sheffield S10 2JF, UK Centre for Respiratory Medicine and Allergy, Institute of Inflammation and Repair, Manchester Academic Health Science Centre, The University of Manchester and University Hospital of South Manchester NHS Foundation Trust, Manchester M23 9LT, UK Sheffield Children's Hospital NHS Foundation Trust, Sheffield S10 2TH, UK Department of ...
متن کاملDetection of early subclinical lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI
lung disease in children with cystic fibrosis by lung ventilation imaging with hyperpolarised gas MRI ABSTRACT Hyperpolarised He ventilationMRI, anatomical lung MRI, lung clearance index (LCI), low-dose CT and spirometry were performed on 19 children (6–16 years) with clinically stable mild cystic fibrosis (CF) (FEV1> −1.96), and 10 controls. All controls had normal spirometry, MRI and LCI. Ven...
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ژورنال
عنوان ژورنال: European Respiratory Journal
سال: 2003
ISSN: 0903-1936,1399-3003
DOI: 10.1183/09031936.03.00049502